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The Effect of Anthocyanin Supplementation on Pro-Inflammatory Biomarkers in Patients With Metabolic Disorders: A
Fatemeh Babaee Kiadehi1, Pegah Samani2, Sanaz Barazandeh3
1Department of Clinical Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction And Aim:
Patients with metabolic disorders benefit from using anthocyanins. Nevertheless, the findings drawn from extant trials remain contentious. Thus, this meta-analysis evaluated anthocyanin's effect on inflammatory biomarkers in patients with metabolic disorders.
Materials And Methods:
We comprehensively searched electronic databases, including PubMed, Scopus, Web of Science, and CENTRAL, from their inception to June 14, 2024.
Findings:
A total of 11 randomized controlled clinical trials with 14 arms were analyzed. There was no significant effect of anthocyanin supplementation on interleukin (IL)-1β levels (standardized mean difference [SMD] = -0.01, 95% CI: -0.33, 0.31; P = 0.941, I 2 = 62.4%, P = 0.031), tumor necrosis factor-α (TNF-α) (SMD = -0.49, 95% CI: -1.07, 0.09; P = 0.098, I 2 = 94.0%, P < 0.001) and IL-6 (SMD = -0.69, 95% CI: -1.45, 0.06; P = 0.073, I 2 = 95.2%, P < 0.001), respectively. A significant between-study heterogeneity was identified, which was reduced when subgrouping by sample size, dosage, and study population. However, subgroup analysis showed that it might decrease TNF-α and IL-6 in patients with hypertension, and if the intervention lasted less than 12 weeks.
Conclusions:
There was no significant impact of anthocyanin supplementation on IL-1β, TNF-α, and IL-6; however, it should be noted that the intervention has a decreasing impact on individuals with hypertension. Our observed effect sizes on IL-1β, TNF-α, and IL-6 are not clinically important.
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