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Identification of Novel Genes Associated with Alginate Production in Pseudomonas aeruginosa Using Mini-himar1 Mariner Transposon-mediated Mutagenesis
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P1 adhesin genotype characteristics of Mycoplasma pneumoniae in China from 2017 to 2019

Shirong Li1, Haiwei Dou1,2, Dawei Shi3

  • 1Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Frontiers in Cellular and Infection Microbiology
|March 4, 2025
PubMed
Abstract

Insights

Mycoplasma pneumoniae P1 adhesin genotype P1-1 is dominant, but P1-2 is increasing in children. No link was found between P1 genotype and community-acquired pneumonia severity.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Mycoplasma pneumoniae is a key cause of community-acquired pneumonia (CAP).
  • P1 adhesin is crucial for M. pneumoniae pathogenicity and immune response.
  • Understanding P1 adhesin genotypes is vital for tracking M. pneumoniae strains.

Purpose of the Study:

  • To investigate P1 adhesin genotypes of M. pneumoniae.
  • To determine the association between P1 genotypes and CAP disease severity.

Main Methods:

  • Real-time quantitative PCR (qPCR) for M. pneumoniae detection.
  • Culture-independent P1 typing method for genotyping.
  • Analysis of 1,907 clinical samples from 2017-2019.

Main Results:

  • M. pneumoniae detected in 43% of samples (820/1907).
  • P1-1 was the dominant genotype (605/797), but P1-2 increased in children (16.75% in 2017 to 28.76% in 2019).
  • No significant association between P1 genotype and CAP severity was observed.

Conclusions:

  • P1-1 remains the predominant M. pneumoniae genotype, with a notable rise in P1-2 among pediatric cases.
  • Genotype surveillance is essential for effective M. pneumoniae infection control strategies.
Keywords:
Mycoplasma pneumoniaeP1 genecommunity-acquired pneumoniagenotypeprevalence

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