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Related Experiment Videos

Sisters with polysplenia.

S M de la Monte, G M Hutchins

    American Journal of Medical Genetics
    |May 1, 1985
    PubMed
    Summary

    The cause of human asplenia and polysplenia is unclear. This study suggests a possible genetic link by examining a family with polysplenia, highlighting the need for further research into these congenital conditions.

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    Area of Science:

    • Developmental Biology
    • Human Genetics
    • Congenital Abnormalities

    Background:

    • The origins of human asplenia (absence of the spleen) and polysplenia (multiple spleens) remain largely unknown.
    • Previous theories proposed duplication of sidedness or abnormal embryonic development.
    • Similarities between human conditions and an autosomal recessive mutation (iv) in mice suggest a potential genetic basis.