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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

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Red blood cells-derived components as biomimetic functional materials: Matching versatile delivery strategies based

Hangbing Liu^1,2, Yi Li¹, Yuli Wang¹

¹Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, People's Republic of China.

Bioactive Materials

|March 4, 2025

Summary

Red blood cells (RBCs) are explored as intelligent drug delivery systems, enhancing biocompatibility and drug targeting. This review details strategies using RBC components for optimized future clinical applications.

Keywords:

Biomimetic Cell membrane Drug delivery Erythrocyte ghosts Hemoglobin Red blood cells derivatives

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Area of Science:

Biomedical Engineering
Drug Delivery Systems
Nanotechnology

Background:

Red blood cells (RBCs) offer unique advantages as drug carriers.
Their inherent biocompatibility and pharmacokinetic profiles are beneficial.
RBCs can be engineered into biological or hybrid drug delivery systems.

Purpose of the Study:

To review drug delivery strategies utilizing RBCs.
To explore applications based on RBC structural and functional properties.
To guide optimization and rational utilization of RBC derivatives in drug delivery.

Main Methods:

Review of existing literature on RBC-based drug delivery.
Analysis of strategies involving intact RBCs, membranes, hollow RBCs, and hemoglobin.
Discussion of drug-loading pathways tailored to RBC characteristics.

Main Results:

RBCs can be modified to improve drug loading and targeting.
Different RBC components (membranes, hemoglobin) offer distinct delivery potentials.
Hybrid systems combining RBCs with other materials show promise.

Conclusions:

RBC-derived materials provide a versatile platform for advanced drug delivery.
Strategic design of drug-loading pathways is crucial for efficacy.
Further research can accelerate clinical translation of RBC-based therapies.