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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jun 22, 2026

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
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Intraoperative nerve imaging with sodium fluorescein.

Roy K Park, Bernardo A Arús, Jennifer Y Lee

    Medrxiv : the Preprint Server for Health Sciences
    |March 4, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Sodium fluorescein, a safe fluorescent agent, significantly improves nerve visualization during surgery. This innovation helps surgeons detect hidden nerves, reducing the risk of nerve damage and enhancing patient recovery.

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    Area of Science:

    • Surgical innovation
    • Medical imaging
    • Neuroscience

    Background:

    • Nerve damage during surgery is a frequent complication.
    • Current nerve identification methods are inadequate for small or hidden nerves.
    • This can lead to chronic pain and functional deficits.

    Purpose of the Study:

    • To evaluate sodium fluorescein as a tool for intraoperative nerve visualization.
    • To assess its efficacy in identifying small or embedded nerve branches.

    Main Methods:

    • Utilized a clinically approved fluorescent agent, sodium fluorescein.
    • Employed both clinical and customized imaging systems for visualization.
    • Assessed nerve contrast enhancement and detection of previously unseen structures.

    Main Results:

    • Sodium fluorescein significantly enhanced nerve contrast during surgery.
    • The agent revealed small nerve branches invisible under white light.
    • Structures embedded within tissues were successfully visualized.

    Conclusions:

    • Sodium fluorescein offers a safe, cost-effective method for improved intraoperative nerve identification.
    • This approach has the potential to minimize nerve injuries and improve surgical outcomes.
    • Immediate clinical applicability is a key advantage.