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Intraoperative nerve imaging with sodium fluorescein
Medrxiv : the Preprint Server for Health Sciences
|March 4, 2025
Summary
Sodium fluorescein, a safe fluorescent agent, significantly improves nerve visualization during surgery. This innovation helps surgeons detect hidden nerves, reducing the risk of nerve damage and enhancing patient recovery.
Area of Science:
- Surgical innovation
- Medical imaging
- Neuroscience
Background:
- Nerve damage during surgery is a frequent complication.
- Current nerve identification methods are inadequate for small or hidden nerves.
- This can lead to chronic pain and functional deficits.
Purpose of the Study:
- To evaluate sodium fluorescein as a tool for intraoperative nerve visualization.
- To assess its efficacy in identifying small or embedded nerve branches.
Main Methods:
- Utilized a clinically approved fluorescent agent, sodium fluorescein.
- Employed both clinical and customized imaging systems for visualization.
- Assessed nerve contrast enhancement and detection of previously unseen structures.
Main Results:
- Sodium fluorescein significantly enhanced nerve contrast during surgery.
- The agent revealed small nerve branches invisible under white light.
- Structures embedded within tissues were successfully visualized.
Conclusions:
- Sodium fluorescein offers a safe, cost-effective method for improved intraoperative nerve identification.
- This approach has the potential to minimize nerve injuries and improve surgical outcomes.
- Immediate clinical applicability is a key advantage.
