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Related Experiment Video

Updated: May 24, 2025

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

Designer mammalian living materials through genetic engineering.

Mariana Gameiro¹, José Almeida-Pinto¹, Beatriz S Moura¹

¹CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.

Bioactive Materials

|March 4, 2025

Summary

Advanced genome editing and synthetic biology enable precise programming of mammalian cells. These engineered cells form the basis for novel biomaterials and living therapeutics with customizable functions.

Keywords:

Genetic engineering Living materials Mammalian cells Synthetic biology Tissue engineering

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Last Updated: May 24, 2025

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

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Mouse Genome Engineering Using Designer Nucleases

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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Area of Science:

Cellular Engineering
Synthetic Biology
Biomaterials Science

Background:

Mammalian cell programming is advancing with genome editing and synthetic biology.
Engineered cells serve as building blocks for cell-dense materials.
These materials have applications in living therapeutics, tissue engineering, and disease modeling.

Purpose of the Study:

To explore advances in genetic engineering for controlling cell behavior.
To discuss the development of next-generation cell-rich materials.
To highlight the potential for user-defined living materials with tailored functionalities.

Main Methods:

Utilizing inside-out engineering approaches for cellular programming.
Leveraging genetic engineering strategies for precise control over cellular functions.
Integrating synthetic biology toolboxes for designing cellular behavior.

Main Results:

Demonstrated accurate programming of mammalian cell behavior from the inside-out.
Enabled the assembly of cell-based materials with enhanced control over cellular arrangements.
Showcased customizable therapeutic capabilities within engineered cell assemblies.

Conclusions:

Inside-out engineering unlocks user-defined living materials with tailored cellular functionalities.
Synergy between inside-out and outside-in approaches will drive sophisticated cell assemblies.
Future developments promise augmented biofunctionalities in engineered cell-based materials.