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Excimer laser therapy for experimental Candida keratitis.

O Serdarevic, R W Darrell, R R Krueger

    American Journal of Ophthalmology
    |May 15, 1985
    PubMed
    Summary
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    The 193-nm excimer laser effectively sterilized experimental Candida albicans keratitis by removing infected tissue. In contrast, the 248-nm wavelength was less effective due to thermal effects, highlighting the 193-nm wavelength's ablative advantage.

    Area of Science:

    • Ophthalmology
    • Microbiology
    • Laser Physics

    Background:

    • Experimental Candida albicans keratitis is a serious ocular infection.
    • Effective treatment strategies are crucial for preventing vision loss.

    Purpose of the Study:

    • To evaluate the efficacy of excimer laser treatment at different wavelengths for Candida albicans keratitis.

    Main Methods:

    • In vivo treatment of experimental Candida albicans keratitis in corneas.
    • Utilized excimer laser at 193-nm and 248-nm wavelengths.
    • Assessed sterilization via culture and histopathology; evaluated tissue effects via light microscopy.

    Main Results:

    • The 193-nm wavelength achieved complete sterilization and tissue removal in all treated corneas.

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  • The 248-nm wavelength failed to eradicate infection, showing incomplete ablation due to thermal effects.
  • Microscopy revealed ulcer healing and stromal integrity at 193-nm, contrasting with incomplete ablation at 248-nm.

    • Conclusions:

    • The 193-nm excimer laser is highly effective for treating Candida albicans keratitis, likely due to precise tissue ablation.
    • The 248-nm wavelength is less effective because of dominant thermal effects, leading to incomplete fungal element removal.