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Unresectable Moderately Differentiated Gallbladder Adenocarcinoma in an Adolescent: A Case Report
Muhammad Sabih1, Ishfaq Ahmad Shah2, Zarafshan Zakir3
1General Surgery, Medical Teaching Institution (MTI) Khyber Teaching Hospital, Khyber Medical College, Peshawar, PAK.
Cureus
|March 4, 2025
Summary
Gallbladder adenocarcinoma is exceptionally rare in adolescents. Early diagnosis and treatment, including surgery and chemotherapy, are vital for improving outcomes in pediatric cases.
Area of Science:
- Oncology
- Pediatric Gastroenterology
Background:
- Gallbladder carcinoma (GBC) is a rare malignancy, predominantly affecting older adults.
- Adenocarcinoma is the most common subtype of GBC.
- Pediatric GBC is exceedingly rare, with limited documented cases.
Observation:
- A 15-year-old male presented with progressive right upper quadrant abdominal pain, jaundice, abdominal distension, anorexia, and weight loss.
- Imaging revealed an infiltrative mass at the porta hepatis.
- Biopsy confirmed moderately differentiated gallbladder adenocarcinoma.
Findings:
- The patient received palliative chemotherapy with gemcitabine and carboplatin, which showed no response.
- Percutaneous transhepatic biliary drainage (PTBD) was performed for symptom management.
- Symptomatic treatment was continued after chemotherapy cessation.
Implications:
- Early diagnosis through sonography and prompt surgical intervention (cholecystectomy) are critical for improving survival in pediatric GBC.
- Adjuvant chemotherapy and advanced molecular techniques like gene panel testing and chemosensitivity assays can optimize treatment strategies.
- Timely medical care is essential to alleviate suffering and prolong survival in young patients with GBC.
