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Late solitary metastasis of chromophobe renal cell carcinoma in the residual ureter.

Yusuke Hakozaki1, Kanako Matsuoka1, Tomoyuki Koguchi1

  • 1Department of Urology Fukushima Medical University School of Medicine Fukushima Japan.

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|March 4, 2025
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Summary
This summary is machine-generated.

Late recurrence of chromophobe renal cell carcinoma (chRCC) in the ureter is rare. This case suggests uroplakin-2-positive chRCC cells may spread and implant in the residual ureter, leading to late metastasis.

Keywords:
late metastasisrenal cell carcinomaresidual ureter

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Chromophobe renal cell carcinoma (chRCC) recurrence is uncommon.
  • The metastatic pathway for chRCC is not well understood.
  • Late solitary metastasis in the ureter presents a diagnostic challenge.

Purpose of the Study:

  • To report a rare case of late solitary metastasis of chRCC.
  • To investigate the potential mechanism of ureteral recurrence in chRCC.
  • To highlight the role of uroplakin-2 in chRCC metastasis.

Main Methods:

  • Nephrectomy for a left renal tumor diagnosed as chRCC.
  • Surgical excision of a recurrent tumor in the residual ureteral stump 9 years postoperatively.
  • Immunohistochemical staining of the recurrent tumor for uroplakin-2.

Main Results:

  • The recurrent tumor was histologically confirmed as chRCC.
  • Tumor cells exhibited high expression of uroplakin-2, a urothelium-specific marker.
  • The recurrent tumor was located in the residual ureteral stump.

Conclusions:

  • Uroplakin-2-positive chRCC cells may spread and adhere to the residual ureter.
  • Slow growth and gradual covering by normal urothelial cells may contribute to late detection.
  • This case provides insight into a possible mechanism for late ureteral recurrence of chRCC.