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Updated: May 24, 2025

High-throughput Protein Expression Generator Using a Microfluidic Platform
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High throughput microparticle production using microfabricated nozzle array.

Süleyman Çelik1,2, Ümit Çelik3, Ali Koşar2,4,5,6

  • 1Department of Molecular Biology and Genetics, Istanbul Technical University 34469 Istanbul Turkey.

RSC Advances
|March 4, 2025
PubMed
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This summary is machine-generated.

A novel microparticle production system (MPS) enables efficient, high-throughput manufacturing of uniform Poly(d,l-lactide-co-glycolide) (PLGA) microparticles for controlled drug delivery. This system shows potential for scalable production of advanced therapeutic technologies.

Area of Science:

  • Biomaterials Engineering
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Polymeric microparticles are crucial for advanced drug delivery, enhancing therapeutic efficacy and reducing side effects.
  • Conventional methods for microparticle fabrication often suffer from issues like size variability, drug degradation, and low production efficiency.

Purpose of the Study:

  • To develop a Microparticle Production System (MPS) integrating precision spraying technology with piezoelectric transducers for high-throughput microparticle fabrication.
  • To characterize the size, morphology, and drug encapsulation/loading efficiencies of Poly(d,l-lactide-co-glycolide) (PLGA) microparticles produced by the MPS.
  • To evaluate the drug release profile and antibacterial efficacy of Chloramphenicol (CHL)-loaded PLGA microparticles.

Main Methods:

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Last Updated: May 24, 2025

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  • Developed an MPS combining precision spraying with a microfabricated nozzle array-based piezoelectric transducer.
  • Utilized Poly(d,l-lactide-co-glycolide) (PLGA) dissolved in dichloromethane (DCM) and dimethyl carbonate (DMC) for microparticle synthesis.
  • Characterized microparticles using scanning electron microscopy (SEM) and focused ion beam (FIB) analyses.
  • Assessed Chloramphenicol (CHL) encapsulation and loading efficiencies, and performed in vitro drug release studies.
  • Evaluated antibacterial activity against Escherichia coli (E. coli).

    • Main Results:

    • Achieved high-throughput production of PLGA microparticles with excellent size uniformity (average diameter 8.9 ± 1.7 μm).
    • SEM and FIB analyses revealed distinct microparticle structures, influenced by solvent volatility.
    • Obtained a Chloramphenicol (CHL) encapsulation efficiency of 38.7% and a loading efficiency of 16.2%.
    • Demonstrated sustained CHL release and effective antibacterial activity against E. coli.

    Conclusions:

    • The developed MPS provides a scalable and efficient method for producing uniform PLGA microparticles.
    • The system facilitates controlled drug release profiles, essential for advanced therapeutic applications.
    • This technology holds significant potential for the industrial-scale production of drug delivery systems.