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Changes in lipoprotein(a) concentrations in patients with acute coronary syndrome

Joanna Satała1, Anna Witkowska2, Agnieszka Pawlos2

  • 1Department of Internal Diseases and Clinical Pharmacology, Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Łódź, Poland. Joanna.satala@umed.lodz.pl

Polish Archives of Internal Medicine
|March 4, 2025
PubMed

Insights

Lipoprotein(a) levels increase significantly 3 months after acute coronary syndrome (ACS). This suggests ACS is a non-genetic factor influencing lipoprotein(a) concentration, impacting cardiovascular risk assessment.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • Lipoprotein(a) (Lp[a]) is an independent cardiovascular disease risk factor.
  • Lp[a] levels, once thought to be solely genetic, may change over time.
  • Current guidelines recommend Lp[a] measurement for cardiovascular risk stratification.

Purpose of the Study:

  • To compare changes in Lp[a] concentration in acute coronary syndrome (ACS) patients.
  • To assess Lp[a] levels at the time of ACS and 3 months post-event.

Main Methods:

  • Forty ACS patients were categorized into STEMI and NSTEMI+UA groups.
  • Routine laboratory methods and ELISA were used to measure Lp(a) and other biomarkers.
  • Lp(a) levels were assessed at ACS onset and 3 months later.

Main Results:

  • Elevated Lp(a) levels (>75 nmol/l) were found in 22.5% of ACS patients, higher in STEMI.
  • All ACS patients exhibited significantly higher serum Lp(a) levels 3 months post-ACS.
  • Significant differences in Lp(a) levels were observed at 3 months compared to ACS onset in STEMI, NSTEMI+UA, and overall ACS groups.

Conclusions:

  • Lp[a] concentration increases 3 months after ACS.
  • Measuring Lp(a) solely at the time of ACS may be insufficient for diagnosis and treatment.
  • Acute coronary syndrome is identified as a non-genetic factor influencing Lp(a) levels.
Abstract

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