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Pentraxin 3: A Marker for the Presence and Severity of Coronary Artery Disease
Taha Okan1, Caner Topaloğlu1, Cihan Altın1
1Department of Cardiology, İzmir Economy University Faculty of Medicine, İzmir, Türkiye.
Insights
Elevated Pentraxin 3 (PTX-3) levels indicate coronary artery disease (CAD) and its severity. This inflammation biomarker shows a strong correlation with coronary artery calcium scoring (CACS), aiding in CAD diagnosis.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation
Background:
- Atherosclerosis, a key driver of coronary artery disease (CAD), involves chronic arterial inflammation.
- Pentraxin 3 (PTX-3) is an inflammation biomarker associated with atherosclerosis and CAD progression.
Purpose of the Study:
- To investigate the association between Pentraxin 3 (PTX-3) levels and the presence and severity of CAD.
- To evaluate PTX-3 as a diagnostic and severity biomarker for CAD using coronary computed tomography angiography (CCTA).
Main Methods:
- 94 participants (54 with CAD, 40 controls) underwent CCTA and coronary artery calcium scoring (CACS).
- Serum PTX-3 levels were measured using enzyme-linked immunosorbent assay (ELISA).
- CAD patients were stratified by CACS into low (<100), intermediate (100-299), and high (≥300) risk groups.
Main Results:
- Serum PTX-3 levels were significantly higher in the CAD group compared to controls.
- A PTX-3 cut-off of 5.80 ng/mL predicted CAD with 68% sensitivity and 66% specificity.
- A strong positive correlation (r=0.521, P<0.001) was found between CACS and PTX-3 levels, with highest levels in the high-risk CACS group.
Conclusions:
- Pentraxin 3 (PTX-3) shows potential as a valuable biomarker for diagnosing coronary artery disease (CAD).
- PTX-3 levels correlate with the severity of CAD, as indicated by CACS.
- Further research may establish PTX-3 as a key indicator in CAD management.
Objective:
Atherosclerosis, a major contributor to coronary artery disease (CAD), is characterized by chronic arterial inflammation. Pentraxin 3 (PTX-3), a biomarker of inflammation, serves as an indicator of both atherosclerosis and the progression of CAD. The aim of this study was to investigate the association between PTX-3 levels and the presence and severity of CAD, as determined by coronary computed tomography angiography (CCTA).
Method:
In this study, 94 participants (54 with CAD and 40 controls) underwent CCTA and coronary artery calcium scoring (CACS) using computed tomography. PTX-3 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. CAD patients were categorized based on CCTA findings and further subdivided into three groups according to their CACS: Group I (CACS < 100), Group II (CACS 100-299), and Group III (CACS ≥ 300).
Results:
Serum PTX-3 levels were significantly higher in the CAD group. A PTX3 cut-off value of 5.80 ng/mL predicted CAD with 68% sensitivity and 66% specificity. A strong positive correlation was observed between CACS and PTX-3 levels (r = 0.521, P < 0.001). In high-risk patients with a CACS ≥ 300, PTX-3 levels were significantly higher than those in low- and intermediate-risk groups a CACS < 300. However, no significant difference in PTX-3 levels was observed between the normal coronary group and the low- and intermediate-risk groups. Furthermore, no correlation was found between the degree of coronary artery stenosis and PTX-3 levels.
Conclusion:
Pentraxin 3 might serve as a valuable biomarker for the diagnosis and severity of CAD.
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