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Implantable hydrogels as pioneering materials for next-generation brain-computer interfaces.
Wasid Ullah Khan1,2, Zhenzhen Shen1,2, Samuel M Mugo3
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China. qiang.zhang@ciac.ac.cn.
Chemical Society Reviews
|March 4, 2025
Summary
Hydrogel electrodes offer a promising solution for brain-computer interfaces (BCIs), overcoming limitations of traditional rigid electrodes. These advanced materials enable stable, high-quality neural recordings and modulation for treating brain disorders.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Materials Science
Background:
- Brain-computer interfaces (BCIs) are crucial for diagnosing and treating brain disorders.
- Traditional rigid electrodes face challenges like foreign body rejection and signal degradation.
- There is a need for advanced materials that improve BCI performance and longevity.
Purpose of the Study:
- To review advancements in implantable hydrogel electrodes for BCIs.
- To highlight the unique properties of hydrogels for neural recording and neuromodulation.
- To discuss the potential of hydrogel electrodes in treating neurological conditions.
Main Methods:
- Review of current literature on hydrogel-based BCI electrodes.
- Analysis of hydrogel properties (mechanical, chemical, electrochemical) relevant to neural interfaces.
- Focus on applications in neural signal recording and neuromodulation.
Main Results:
- Hydrogels mimic brain tissue properties, offering superior biocompatibility and flexibility.
- They enable stable, high-quality neural recordings and effective neural modulation.
- Hydrogel electrodes address limitations of traditional rigid materials.
Conclusions:
- Implantable hydrogel electrodes represent a significant advancement for BCIs.
- They hold great potential for revolutionizing neural monitoring, neuromodulation, and brain function restoration.
- Further development is encouraged to drive innovation in treating brain disorders.
