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Related Concept Videos

Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Multi-Functional Responsive Microcapsules with Sequential Release Capacity for Wound Healing.

Chengkai He1, Xiang Lin1, Luoran Shang1,2

  • 1The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China.

Small (Weinheim an Der Bergstrasse, Germany)
|March 4, 2025
PubMed
Summary
This summary is machine-generated.

This study presents novel black phosphorus-laden microcapsules for advanced wound healing. These biomaterials offer on-demand delivery of therapeutic agents, accelerating healing and improving outcomes.

Keywords:
drug deliveryelectrospraymicrocarriersmicrofluidicswound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Advanced wound therapy requires biomaterials with precise, on-demand drug delivery capabilities.
  • Current research focuses on enhancing structural design for controlled release of active agents to promote wound healing.

Purpose of the Study:

  • To develop and evaluate novel microcapsules for accelerated wound healing using a coaxial microfluidic electrospray technique.
  • To incorporate black phosphorus (BP) for photothermal sterilization and vascular endothelial growth factor (VEGF) for angiogenesis.

Main Methods:

  • Fabrication of core-shell microcapsules using coaxial microfluidic electrospray.
  • Encapsulation of curcumin nanoparticles (CNPs) and VEGF within BP-laden alginate shell and GelMA core, respectively.
  • In vivo assessment of microcapsule efficacy in a rat wound model.

Main Results:

  • The microcapsules demonstrated effective photothermal sterilization and angiogenic effects.
  • Significant acceleration of wound healing, enhanced collagen deposition, and modulated inflammatory responses were observed.
  • The biomaterial design facilitated controlled release of active agents for dual-stage wound therapy.

Conclusions:

  • The developed BP-laden microcapsules show significant potential for clinical application in wound therapy.
  • The combination of photothermal properties and growth factor delivery offers a promising strategy for advanced wound management.
  • On-demand delivery biomaterials represent a key advancement in facilitating efficient wound healing.