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Related Experiment Video

Updated: May 24, 2025

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities
07:13

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Size-Controlled Self-Assembly for Bimodal In Vivo Imaging.

Antonia Albers1, Shivadharshini Kuberasivakumaran2, Zulema Fernández1

  • 1Universität Münster, Organisch-Chemisches Institut, Corrensstraße 36, 48149, Münster, Germany.

Angewandte Chemie (International Ed. in English)
|March 4, 2025
PubMed
Summary
This summary is machine-generated.

New dye assemblies act as contrast agents for simultaneous multimodal and multiscale biomedical imaging. These self-assembling aza-BODIPY nanostructures offer tunable properties and excellent biocompatibility for advanced diagnostics.

Keywords:
Amphiphilic systemsAqueous self‐assemblyBiomedical imagingNanostructuresπ‐conjugated systems

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Contrast agents (CAs) are crucial for disease diagnosis and therapy monitoring in biomedical imaging.
  • Current CAs are limited to single modalities and possess fixed properties, hindering comprehensive biological process visualization.
  • Developing versatile CAs is essential for advancing diagnostic capabilities.

Purpose of the Study:

  • To introduce a novel platform of rationally designed dye assemblies for simultaneous multimodal and multiscale biomedical imaging.
  • To synthesize amphiphilic aza-BODIPY dyes and investigate their self-assembly into nanostructures with tunable properties.
  • To establish the utility of these nanostructures for advanced in vitro and in vivo imaging applications.

Main Methods:

  • Synthesis of amphiphilic aza-BODIPY dyes with varying hydrophobic alkyl chain lengths (C1, C8, C12, C16).
  • Characterization of self-assembly into nanostructures in aqueous media with tunable size (50 nm-1 µm) and photophysical properties.
  • Establishment of fluorescence reflectance and photoacoustic imaging (in vitro and in vivo), cell viability assays, and biodistribution studies.

Main Results:

  • Aza-BODIPY dyes self-assembled into nanostructures with J-type aggregation, exhibiting near-infrared (NIR) absorption/emission and photoacoustic properties (C8-C16).
  • Demonstrated successful semi-quantitative fluorescence reflectance and photoacoustic imaging in vitro and in vivo.
  • Confirmed excellent biocompatibility and size-dependent biodistribution of nanostructures in vivo.

Conclusions:

  • Rationally designed aza-BODIPY dye assemblies provide a versatile platform for multimodal and multiscale biomedical imaging.
  • The self-assembly approach allows for tunable nanostructure size and photophysical properties, overcoming limitations of traditional CAs.
  • This technology holds significant potential for addressing complex biomedical questions and advancing diagnostic imaging.