Related Experiment Video

Updated: Jul 21, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 18, 2013

Effect of cell turnover and leaky junctions on arterial macromolecular transport

S Weinbaum, G Tzeghai, P Ganatos

    The American Journal of Physiology
    |June 1, 1985
    PubMed

    Keywords:
    vascular permeabilityendothelial junctionsmacromolecule transportcell turnover effects

    More Related Videos

    Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow11:26

    Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow

    Published on: August 14, 2014

    Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery12:48

    Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery

    Published on: September 12, 2015

    Related Concept Videos

    Membrane Fluidity01:26

    Membrane Fluidity

    Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
    Mosaic nature of the membrane
    The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
    Protein Diffusion in the Membrane01:24

    Protein Diffusion in the Membrane

    Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
    The Significance of Membrane Transport01:44

    The Significance of Membrane Transport

    The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
    Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
    Introduction to Membrane Traffic01:44

    Introduction to Membrane Traffic

    The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
    The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
    Membrane Asymmetry Regulating Transporters01:19

    Membrane Asymmetry Regulating Transporters

    Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
    Flippase
    Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
    Cellular Membranes and Drug Transport01:24

    Cellular Membranes and Drug Transport

    Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
    Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.