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Copper-Mediated Phosphoniumation of Aryl/Vinyl Boronic Acids
Dongchang Han1, Ao Wen1, Ziheng Tian1
1School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Abstract:
Following the successful construction of nitrilium/pyridinium and sulfonium salts, the Chan-Lam coupling has been significantly advanced with the first demonstration of quaternary phosphonium salt synthesis. We present a method employing copper(II) acetate in trifluoroethanol to efficiently produce a range of aryl and vinyl phosphonium salts from boronic acids, including those derived from complex natural products, thus overcoming phosphine oxidation issues and expanding the scope to functionalized phosphorus.
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