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Updated: May 24, 2025

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy
Hao Yuan1, Qun Chen1, Kuirong Jiang2
1Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Abstract:
The shared HLA-bound neoepitopes in pancreatic ductal adenocarcinoma (PDAC) represent a novel class of noncanonical antigens with single amino acid substitutions resulting from translational errors. These peptides, shared across patients with PDAC, showed higher immunogenicity than wild-type counterparts, offering potential candidates for specific immunotherapy development in PDAC. See related article by Zhang et al., p. 1956.
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