Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

204
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
204
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

422
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
422
Analgesia and Pain Management01:25

Analgesia and Pain Management

422
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
422
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

160
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
160
Healthcare Agencies II01:17

Healthcare Agencies II

678
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
678
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

422
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
422

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DXA-Measured Visceral Adipose Tissue and Accelerated Biological Aging in Middle-Aged Adults.

Obesity (Silver Spring, Md.)·2026
Same author

Multisite Mobile Addiction Services: Four-Year Outcomes.

International journal of environmental research and public health·2026
Same author

Effectiveness of lay workers delivering behavioural activation for people with depression: systematic review and meta-analysis.

BJPsych open·2026
Same author

Multimorbidity, physical function, and risk of falls in middle-aged adults.

Bone·2026
Same author

Pharmacokinetics of xylazine and fentanyl in patients presenting to the emergency department after non-fatal opioid overdose.

Drug and alcohol dependence·2026
Same author

Incidence, risk factors and management of paradoxical reaction in central nervous system tuberculosis in the United Kingdom.

The Journal of infection·2026
Same journal

Characterizing pediatric trauma patients and EMS agencies that are optimal targets for prehospital pediatric blood transfusion programs.

Prehospital emergency care·2026
Same journal

Disparities in Pediatric Out-of-Hospital Cardiac Arrest Outcomes Relating to Race, Urbanicity, and Poverty: A Study of the NEMSIS Database.

Prehospital emergency care·2026
Same journal

Hypopharyngeal Perforation Associated with King Laryngeal Tube Use in Prehospital Cardiac Arrest Management.

Prehospital emergency care·2026
Same journal

Prehospital physiologic instability and in-hospital mortality among non-trauma patients with low-risk emergency department triage.

Prehospital emergency care·2026
Same journal

The 2026 Core Content of Emergency Medical Services Medicine.

Prehospital emergency care·2026
Same journal

Prehospital Assessment and Treatment of Infants and Toddlers in Respiratory Distress: A Retrospective Analysis.

Prehospital emergency care·2026
See all related articles

Related Experiment Video

Updated: May 24, 2025

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
10:35

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

11.1K

Creating Opioid Response Specialists: A Harm Reduction Initiative.

John P Broach1,2, Brian Rettger2,3, Ronald Gigliotti2,3

  • 1University of Massachusetts Chan Medical School, Worcester, Massachusetts.

Prehospital Emergency Care
|March 4, 2025
PubMed
Summary
This summary is machine-generated.

The Opioid Response Specialist (ORS) program, integrated with mobile addiction services, improved harm reduction access and opioid use disorder treatment uptake. This model shows potential for training emergency medical services (EMS) personnel to enhance overdose response.

More Related Videos

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.5K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.2K

Related Experiment Videos

Last Updated: May 24, 2025

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
10:35

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

11.1K
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.5K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.2K

Area of Science:

  • Public Health
  • Addiction Medicine
  • Emergency Medical Services

Background:

  • Over 100,000 annual overdose deaths in the US, primarily from high-potency opioids like fentanyl.
  • Significant barriers to treatment for people who use drugs, including access and negative medical experiences.
  • Worcester County, MA experienced a sharp rise in overdose deaths in 2022, necessitating innovative interventions.

Purpose of the Study:

  • To develop and implement an Opioid Response Specialist (ORS) Program within a mobile addiction service.
  • To address the increasing overdose crisis in Worcester County, Massachusetts.
  • To evaluate the impact of integrating ORS personnel into existing mobile addiction services.

Main Methods:

  • The Mobile Addiction Service, staffed by physicians and advanced practice providers, offers low-barrier access to medications for opioid use disorder (MOUD) and harm reduction resources.
  • Two care givers with emergency medical services (EMS) experience, also working as paramedics, formed the ORS team.
  • A curriculum for the ORS role was developed, and pilot testing was conducted within the mobile service, training specialists to paramedic level with added expertise in overdose reversal and patient care.

Main Results:

  • Increased distribution of naloxone and sterile syringes.
  • Enhanced screening rates for Hepatitis C and Human Immunodeficiency Virus.
  • Facilitated uptake of opioid use disorder treatment interventions by city EMS, improving city-wide naloxone distribution and buprenorphine/naloxone use post-overdose reversal.

Conclusions:

  • The Opioid Response Specialist (ORS) model, particularly when integrated with mobile addiction services, shows promise for improving harm reduction access.
  • This program can serve as a foundation for training EMS personnel, expanding their skills and scope in addressing the opioid crisis.
  • The initiative demonstrated a positive impact on overdose response and treatment engagement within the community.