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Distinct inflammatory pathways shape atherosclerosis in different vascular beds

Oliver Soehnlein1, Esther Lutgens2,3, Yvonne Döring3,4,5,6

  • 1Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), Von-Esmarch-Str. 56, University of Münster, 48149 Münster, Germany.

European Heart Journal
|March 4, 2025
PubMed

Insights

Atherosclerotic cardiovascular disease (ASCVD) varies by artery location. This review explores immune-inflammatory factors driving ASCVD in different arterial beds for tailored treatments in aging populations.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Vascular Biology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) prevalence and characteristics differ across various arterial beds.
  • Factors like smoking, diabetes, and hypertension uniquely influence ASCVD progression in specific arteries.

Purpose of the Study:

  • To review current literature on immune-inflammatory mechanisms in ASCVD across different arterial beds.
  • To highlight the need for patient-specific and vascular bed-specific treatment strategies.

Main Methods:

  • Literature review of studies on ASCVD and immune-inflammatory pathways.
  • Comparative analysis of ASCVD characteristics across abdominal aorta, coronary, carotid, and lower limb arteries.

Main Results:

  • ASCVD progression rates and lesion characteristics (e.g., calcification, cholesterol) vary significantly between arterial beds.
  • Distinct immune-inflammatory pathways are implicated in ASCVD development in different vascular locations.

Conclusions:

  • Understanding differential immune-inflammatory mechanisms is crucial for developing targeted ASCVD therapies.
  • Vascular bed-specific and patient-specific treatment approaches are essential, particularly for aging populations.

Keywords:
AtherosclerosisCalcificationCardiovascular diseaseCarotidCoronaryFemoral arteriesInflammation

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