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Related Experiment Videos

"Localized" leishmania lymphadenitis: a light and electron microscopic study.

B Azadeh

    The American Journal of Tropical Medicine and Hygiene
    |May 1, 1985
    PubMed
    Summary

    This study reports nineteen cases of localized leishmania lymphadenitis, a form of leishmaniasis affecting lymph nodes without systemic involvement. Histopathology revealed varied immune responses, aiding differential diagnosis.

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    Histopathology·2004

    Area of Science:

    • Infectious Diseases
    • Parasitology
    • Immunology

    Background:

    • Leishmania lymphadenitis can present without overt signs of visceral leishmaniasis.
    • Cutaneous leishmaniasis is often subtle or overlooked in these cases.
    • The condition exhibits seasonal incidence, typically from late summer to mid-winter.

    Purpose of the Study:

    • To describe nineteen cases of localized leishmania lymphadenitis.
    • To analyze clinical presentation, serological findings, and histopathological features.
    • To differentiate leishmania lymphadenitis from other conditions like toxoplasmosis and cat-scratch disease.

    Main Methods:

    • Clinical case series analysis.
    • Serum leishmanial antibody testing using immunofluorescence antibody test (IFAT).
    • Histopathological examination of lymph node biopsies, including electron microscopy.

    Main Results:

    • Nineteen patients (15 males, 4 females, aged 5-30) presented with lymphadenopathy.
    • IFAT was positive in 12 cases; Toxoplasma serology was negative.
    • Histopathology showed diverse granulomatous responses, with varying degrees of necrosis and presence of amastigotes.

    Conclusions:

    • Localized leishmania lymphadenitis is a distinct clinical entity.
    • Histopathological findings correlate with responses seen in cutaneous leishmaniasis.
    • Accurate diagnosis requires consideration of clinical, serological, and histological data.

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