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Prevalence and Associated Factors for Depression Among Patients With Sarcoma.

Michael J Robinson1, Sang Minh Nguyen2, Debra L Friedman1

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Depression symptoms are more common in younger sarcoma patients, marijuana users, and those with lower incomes. Regular exercise and emotional support can help reduce these symptoms in sarcoma survivors.

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Area of Science:

  • Oncology
  • Psychiatry
  • Epidemiology

Background:

  • Depression prevalence and risk factors in sarcoma patients and survivors are not well understood.
  • Sarcoma survivorship presents unique challenges that may impact mental health.
  • Characterizing depression is crucial for developing targeted supportive care strategies.

Purpose of the Study:

  • To determine the prevalence of depression symptoms in a sarcoma survivorship cohort.
  • To identify demographic, lifestyle, and clinical risk factors associated with depression symptoms in sarcoma survivors.
  • To inform the development of personalized interventions for depression in this population.

Main Methods:

  • A cohort of 612 sarcoma patients diagnosed between April 2022 and September 2023 was established.
  • Depression symptoms were assessed using the Patient-Reported Outcomes Measurement Information System-57 (PROMIS-57) depression scale.
  • Multinomial logistic regression models analyzed associations between depression T-scores and various patient characteristics.

Main Results:

  • 13.2% of participants had clinically significant depression symptoms (T-score ≥60).
  • Younger age (18-59 years), marijuana use, and lower household income were associated with higher depression scores.
  • Regular exercise and greater emotional support were inversely associated with depression symptoms.

Conclusions:

  • Younger sarcoma patients, marijuana users, and individuals with lower incomes exhibit a higher prevalence of depression symptoms.
  • Lifestyle factors such as regular exercise and emotional support play a significant role in mitigating depression.
  • Findings support the need for tailored supportive care strategies to address depression in sarcoma survivors.