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Related Concept Videos

Gene Families01:57

Gene Families

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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Globular and Fibrous Proteins02:21

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Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
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Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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PIGOME: An Integrated and Comprehensive Multi-omics Database for Pig Functional Genomics Studies.

Guohao Han1,2,3, Peng Yang1,2,3,4,5, Yongjin Zhang2,3

  • 1Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute, Chinese Academy of Agricultural Sciences, Foshan 528225, China.

Genomics, Proteomics & Bioinformatics
|March 4, 2025
PubMed
Summary

PIGOME is a new database offering diverse pig multi-omics data for functional genomics. This resource aids pig breeding and human biomedical research by providing integrated gene annotation and visualization tools.

Keywords:
DatabaseEpigeneticsGene expressionGenomeMulti-omicsPig

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Area of Science:

  • Genomics
  • Bioinformatics
  • Animal Science

Background:

  • Pigs are vital protein sources and crucial models for human development and disease research.
  • Extensive high-throughput sequencing in pigs has generated vast data, but dedicated multi-omics databases remain limited.
  • Functional genomics research in pigs requires integrated, accessible omics datasets.

Purpose of the Study:

  • To introduce PIGOME, a comprehensive and user-friendly database for pig multi-omics data.
  • To consolidate diverse omics datasets and associated metadata for enhanced pig functional genomics research.
  • To provide tools for exploring gene expression, epigenetic patterns, and trait associations in pigs.

Main Methods:

  • Compilation of seven types of pig omics datasets: WGS, RNA-seq, miRNA-seq, ChIP-seq, ATAC-seq, BS-seq, and MeRIP-seq.
  • Integration of data from 6901 samples across 392 projects with curated metadata, gene annotation, and QTL information.
  • Development of user-friendly 'Explore' and 'Browse' functions and visualization tools for genomic variants, gene expression, and epigenetic signals.

Main Results:

  • PIGOME houses a substantial collection of pig multi-omics data with rich metadata.
  • The database offers integrated gene annotation and quantitative trait locus (QTL) information.
  • Visualization tools enable efficient exploration of spatiotemporal gene expression, epigenetic patterns, and regulatory mechanisms.

Conclusions:

  • PIGOME serves as a valuable resource for advancing pig functional genomics and breeding strategies.
  • The database facilitates research into pig development, diseases, and economic traits.
  • PIGOME supports comparative genomics and human biomedical research by leveraging pig as a model organism.