Reference Intervals for 24-Hour Urinary Calcium Excretion and Its Association With Bone Metabolism: A Multicenter...

Area of Science:

• Endocrinology
• Metabolic Health
• Bone Metabolism

Background:

• 24-hour urinary calcium excretion (UCaE) is crucial for calcium metabolism and linked to metabolic diseases.
• The distribution and bone metabolism associations of 24-hour UCaE remain unclear.

Purpose of the Study:

• To investigate the distribution of 24-hour UCaE in the Chinese population.
• To explore the association between 24-hour UCaE and bone metabolism.

Main Methods:

• A multicenter cross-sectional study involving 1239 participants.
• Multivariate linear regression and restrictive cubic splines were used to analyze UCaE/Ucr and bone metabolism markers.
• Data collected from 9 tertiary hospitals.

Main Results:

• Established reference intervals for 24-hour UCaE in the Chinese population.
• Found positive associations between 24-hour UCaE/urinary creatinine (UCaE/Ucr) and 25(OH)D in both genders.
• Identified associations between UCaE/Ucr and parathyroid hormone (PTH), β-CTX, and P1NP in men, but not women.
• Prevalence of hypercalciuria was 11.6%, varying by age and region.

Conclusions:

• Established reference intervals for 24-hour UCaE in the Chinese population.
• Demonstrated gender-specific relationships between 24-hour UCaE and bone metabolism markers.
• Highlights the importance of considering gender in calcium and bone health assessments.