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MicroRNA-126: From biology to therapeutics

Bei Guo1, Jia Gu2, Tongtian Zhuang3

  • 1Department of Metabolism and Endocrinology, General Hospital of Northern Theater Command, Shenyang, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 4, 2025
PubMed

Insights

MicroRNA-126 (miR-126) is vital in human diseases like cancer and vascular disorders. Understanding its roles in cell processes and disease is key for clinical applications and developing miR-126 therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNA-126 (miR-126) is a highly conserved non-coding RNA with critical roles in human health and disease.
  • It is extensively studied for its involvement in vascular disorders and various cancers.

Purpose of the Study:

  • To synthesize current research on miR-126's functions in biological processes.
  • To evaluate miR-126's potential as a biomarker and therapeutic target for diseases.
  • To highlight the clinical significance of miR-126.

Main Methods:

  • Systematic review and synthesis of findings from 283 scientific articles.
  • Analysis of miR-126's molecular mechanisms in physiological and pathological contexts.

Main Results:

  • miR-126 modulates angiogenesis, immune response, inflammation, tumor growth, and metastasis.
  • It plays a causal role in disease pathogenesis and influences cell development, survival, cycle regulation, proliferation, migration, invasion, communication, and metabolism.
  • miR-126 is a potential biomarker for disease prediction, diagnosis, prognosis, and drug response.

Conclusions:

  • miR-126 is a significant factor in numerous biological processes and disease development.
  • It holds promise as a therapeutic agent and a predictive biomarker for various conditions.
  • Further research into miR-126 is essential for its clinical translation.
Keywords:
AngiogenesisBiomarkerImmune responseInflammation responseMicroRNA-126Therapeutic targetTumor growth and metastasis

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