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  1. Home
  3. Diosmetin Alleviates Afb1-induced Endoplasmic Reticulum Stress, Autophagy, And Apoptosis Via Pi3k/akt Pathway In Mice.
  1. Home
  3. Diosmetin Alleviates Afb1-induced Endoplasmic Reticulum Stress, Autophagy, And Apoptosis Via Pi3k/akt Pathway In Mice.

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Diosmetin alleviates AFB1-induced endoplasmic reticulum stress, autophagy, and apoptosis via PI3K/AKT pathway in

Zhenlin Li1, Mengjie Liu2, Jie Li1

  • 1Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.

Ecotoxicology and Environmental Safety
|March 4, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Diosmetin (DIOS) effectively protects against Aflatoxin B1 (AFB1)-induced liver damage. This study shows DIOS mitigates AFB1 toxicity by reducing oxidative stress, inflammation, and apoptosis, offering a potential therapeutic strategy for mycotoxin-related liver injury.

Keywords:
Aflatoxin B1 (AFB1)AutophagyDiosmetin (DIOS)Endoplasmic reticulum (ER) stressPI3K/AKT

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Area of Science:

  • Toxicology
  • Pharmacology
  • Hepatology

Background:

  • Aflatoxin B1 (AFB1) is a dangerous mycotoxin causing significant health risks.
  • Diosmetin (DIOS), a natural flavonoid, shows promise for liver protection.

Purpose of the Study:

  • To investigate the protective mechanisms of Diosmetin against AFB1-induced hepatotoxicity in a mouse model.
  • To elucidate how DIOS counteracts AFB1's detrimental effects on the liver.

Main Methods:

  • Mice were treated with AFB1, DIOS, or a combination over 28 days.
  • Evaluated liver injury markers, oxidative stress, endoplasmic reticulum (ER) stress, apoptosis, and autophagy.
  • Assessed inflammatory cytokine levels and key signaling pathways (NF-κB, PI3K/AKT).

Main Results:

  • AFB1 induced significant liver injury, oxidative stress, ER stress, apoptosis, and autophagy.
  • DIOS treatment ameliorated liver damage, reduced oxidative stress markers, and decreased inflammation (IL-1β, TNF-α) by inhibiting the NF-κB pathway.
  • DIOS alleviated ER stress and apoptosis by modulating key proteins and promoted hepatoprotection via the PI3K/AKT pathway.

Conclusions:

  • Diosmetin effectively mitigates AFB1-induced hepatotoxicity through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
  • DIOS demonstrates potential as a therapeutic agent for preventing liver damage caused by AFB1 exposure.
  • The findings highlight DIOS's role in modulating critical cellular stress pathways for liver health.