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Changes in the thickness of the crystalline lens components before and after cycloplegia in children with different
Yongle Bao1, Zhirong Zhang2, Jian Cao2
1Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China; Key laboratory of Myopia and Related Eye Diseases, NHC, Shanghai, China; Key laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care, Shanghai, China; Department of Ophthomology, Zhangye People's Hospital, Hexi University, Zhangye, Gansu, China; Clinical Medical College, Hexi University, Zhangye, Gansu, China.
Insights
Cycloplegia significantly reduced lens thickness (LT) and lens nucleus thickness (LNT) in children with non-myopia and low-myopia. Anterior and posterior cortex thicknesses did not change significantly, and refractive error correlated with LT and LNT.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Refractive Error Research
Background:
- Crystalline lens thickness changes can influence refractive error development in children.
- Understanding these changes is crucial for managing pediatric vision.
- Cycloplegia is commonly used to assess refractive error and ocular parameters in children.
Purpose of the Study:
- To investigate the impact of cycloplegia on crystalline lens component thickness in children with varying refractive errors.
- To determine if changes in lens thickness correlate with spherical equivalent (SE).
Main Methods:
- A prospective study involving 132 children (ages 5-15) with refractive errors from -6.00 D to +6.75 D.
- Eyes were categorized into non-myopia, low-myopia, and moderate-myopia groups.
- Optical coherence tomography measured lens thickness (LT), lens nucleus thickness (LNT), anterior cortex thickness (ACT), and posterior cortex thickness (PCT) before and after 0.5% tropicamide-induced cycloplegia.
Main Results:
- LT and LNT significantly decreased in non-myopia and low-myopia groups after cycloplegia (P < 0.05).
- No significant changes in LT or LNT were observed in the moderate-myopia group.
- ACT and PCT showed no significant cycloplegia-induced changes across all groups.
- Spherical equivalent (SE) positively correlated with LT and LNT both before and after cycloplegia.
Conclusions:
- Cycloplegia induces significant reductions in LT and LNT in children with non-myopia and low-myopia.
- ACT and PCT remain stable during cycloplegia in pediatric eyes.
- The findings highlight a relationship between refractive error and lens dimensions, particularly LT and LNT.
Objective:
To evaluate changes in the thickness of the crystalline lens components in children with different refractive errors before and after cycloplegia.
Methods And Analysis:
This prospective study recruited 132 right eyes from 132 children (age 5-15 years) with different spherical equivalent (SE) ranging from -6.00 diopters (D) to +6.75 D. We categorized these eyes into non-myopia (N = 30), low-myopia (N = 77), and moderate-myopia (N = 25) groups. The thickness parameters of the crystalline lens components, including lens thickness (LT), lens nucleus thickness (LNT), anterior cortex thickness (ACT), and posterior cortex thickness (PCT), were assessed using optical coherence tomography before and after 0.5 % tropicamide-induced cycloplegia.
Results:
After cycloplegia, LT significantly decreased from 3.47 ± 0.20 to 3.41 ± 0.20 mm in non-myopia eyes (P < 0.05), and from 3.30 ± 0.17 to 3.27 ± 0.16 mm in low-myopia eyes (P < 0.05), with no significant changes in moderate-myopia eyes (P < 0.05). LNT decreased from 3.15 ± 0.19 to 3.09 ± 0.19 mm in non-myopia eyes (P < 0.05), and from 3.02 ± 0.20 to 2.99 ± 0.17 mm in low-myopia eyes (P < 0.01), with no reduction observed in moderate-myopia eyes (P > 0.05). Cycloplegia-induced changes in ACT and PCT (all P > 0.05) did not differ significantly between the groups. SE was positively correlated with LT and LNT before (Pearson's r = 0.353 and 0.272, respectively; both P < 0.05) and after cycloplegia (r = 0.285 and 0.198, respectively; both P < 0.05).
Conclusions:
LT and LNT significantly decreased after cycloplegia induced by 0.5 % tropicamide in children with non-myopia and low-myopia, while neither ACT nor PCT changed significantly. SE was positively correlated with LT and LNT.
