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Updated: May 24, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Deep learning models for improving Parkinson's disease management regarding disease stage, motor disability and
Helena R Gonçalves1, Pedro Pinheiro1, Cristiana Pinheiro1
1Center for MicroElectroMechanical Systems, University of Minho, Guimarães, Portugal.
Background And Objective:
Motor diagnosis, monitoring and management of Parkinson's disease (PD) focuses mainly on observational methods and, clinical scales, resulting in a subjective evaluation. Inertial sensors combined with artificial intelligence have emerged as a promising solution to help physicians perform early, differential, and objective quantification of motor symptoms over time. We hypothesize that a long short-term memory-deep neural network (LSTM) architecture could be an appropriate solution for producing three models to provide a holistic assessment of patients with PD from a single inertial sensor.
Methods:
A custom dataset with 40 patients was created to train and test three deep learning models to classify PD disease stages, motor conditions and quality of life (QoL).
Results:
We verified an accuracy of 89 % for the disease stage classifier, 91.7 % for the motor condition classifier, and an accuracy of 87.8 % for the QoL classifier.
Conclusions:
We confirmed that an LSTM architecture could produce three models to improve PD management.
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