Designing flexible aliphatic linker based molecular imprinted covalent organic framework for rapid and selective
Li-Hong Su1, Hai-Long Qian2, Shu-Ting Xu1
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China; Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Abstract:
Food and environment contaminations by zearalenone (ZEN) has aroused serious issues in public health. Sensitive and accurate detection of ZEN remains a daunting challenge due to complex interference and low residue in real samples. Herein, we report a novel molecular imprinted covalent organic framework with flexible aliphatic linkers (ALCOF-MIP) for rapid and selective extraction of ZEN in real samples. Flexible aliphatic linkers were employed to regulate the molecular conformation and enhance hydrophily, enabling ALCOF-MIP to possess high selectivity and fast kinetics for ZEN extraction. ALCOF-MIP with selective imprinting sites displayed the maximum adsorption capacity for ZEN (1250 mg g-1, exceeding most of reported adsorbents). Furthermore, the ALCOF-MIP based solid-phase extraction coupled with high-performance liquid chromatography gave a wide linear range (1-500 ng mL-1), low detection limit (0.06 ng mL-1) and high precision (≤3.2 %). The recovery of spiked ZEN in real samples ranged from 90.7 % to 99.1 %. The proposed method is promising for monitoring mycotoxin residues and assessing food safety without matrix interferences.
