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Updated: May 24, 2025
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Texture-based probability mapping for automatic assessment of myocardial injury in late gadolinium enhancement images
Vidar Frøysa1, Gøran J Berg2, Erlend Singsaas3
1Department of Cardiology, Stavanger University Hospital, Armauer Hansens vei 20, 4011 Stavanger, Norway.
Background:
Late Gadolinium-enhancement in cardiac magnetic resonance imaging (LGE-CMR) is the gold standard for assessing myocardial infarction (MI) size. Texture-based probability mapping (TPM) is a novel machine learning-based analysis of LGE images of myocardial injury. The ability of TPM to assess acute myocardial injury has not been determined.
Objectives:
This proof-of-concept study aimed to determine how TPM responds to the dynamic changes in myocardial injury during one-year follow-up after a first-time revascularized acute MI.
Methods:
41 patients with first-time acute ST-elevation MI and single-vessel occlusion underwent successful PCI. LGE-CMR images were obtained 2 days, 1 week, 2 months, and 1 year following MI. TPM size was compared with manual LGE-CMR based MI size, LV remodeling, and biomarkers.
Results:
TPM size remained larger than MI by LGE-CMR at all time points, decreasing from 2 days to 2 months (p < 0.001) but increasing from 2 months to 1 year (p < 0.01). TPM correlated strongly with peak Troponin T (p < 0.001) and NT-proBNP (p < 0.001). At 1 week, 2 months, and 1 year, TPM showed a stronger correlation with NT-proBNP than MI size by LGE-CMR. Analyzing all collected pixels from 2 months to 1 year revealed a general increase in pixel scar probability in both the infarcted and non-infarcted regions.
Conclusion:
This proof-of-concept study suggests that TPM may offer additional insights into myocardial alterations in both infarcted and non-infarcted regions following acute MI. These findings indicate a potential role for TPM in assessing the overall myocardial response to infarction and the subsequent healing and remodeling process.
