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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
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Measuring Delay Discounting in Humans Using an Adjusting Amount Task
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Published on: January 9, 2016

Frandsen et al. respond to "A note on variable adjustments".

Clarissa L B Frandsen1,2, Mathilde Gottschau1, Bugge Nøhr2

  • 1Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

American Journal of Epidemiology
|March 4, 2025
PubMed
Summary

Polycystic ovary syndrome (PCOS) may increase endometrial cancer risk. Further research is needed to explore hormone therapy and gynecological visit frequency

Keywords:
PCOSadjustmentscohort studyendometrial cancervariable confounder

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Area of Science:

  • Reproductive Endocrinology
  • Gynecologic Oncology

Background:

  • Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with various health risks.
  • The relationship between PCOS and endometrial cancer risk requires further elucidation.
  • Previous studies have not fully accounted for factors like hormone therapy and healthcare utilization.

Purpose of the Study:

  • To address critiques of a prior study on PCOS and endometrial cancer risk.
  • To highlight areas for future research, including the role of hormone therapy and gynecological visit frequency.
  • To refine understanding of the complex interplay between PCOS and endometrial cancer.

Main Methods:

  • The study utilized nationwide cohort data.
  • Analysis focused on the association between PCOS and endometrial cancer.
  • Critiques suggest incorporating hormone therapy and gynecological visit data.

Main Results:

  • The original study's findings on PCOS and endometrial cancer risk are acknowledged.
  • Potential for surveillance bias due to the treatment of gynecological visits as a mediator was identified.
  • Underestimation of the true association may occur due to reliance on hospital records.

Conclusions:

  • Acknowledging limitations and critiques is crucial for advancing research.
  • Future studies should incorporate hormone therapy and detailed healthcare utilization data.
  • Further research is necessary to fully understand the PCOS-endometrial cancer link.