Luminescent Metal-Organic Framework with Negative Electrostatic Pores for Highly Selective GDP Sensing

Area of Science:

• Materials Science
• Chemical Sensing
• Nanotechnology

Background:

• Electrostatic potential (ESP) is crucial for molecular interactions.
• Developing selective probe materials based on ESP is vital but underexplored.
• Metal-organic frameworks (MOFs) offer tunable properties for sensing applications.

Purpose of the Study:

• To synthesize a luminescent metal-organic framework (LMOF) with a negative electrostatic pore environment.
• To develop a selective sensor for guanosine diphosphate (GDP) based on ESP matching.
• To provide theoretical guidance for designing efficient MOF-based sensors.

Main Methods:

• Synthesis of a luminescent MOF (Cd-DBDP) with electronegative pore environments.
• Calculation of molecular ESP distributions for the MOF and nucleotides.
• Fluorescence spectroscopy for sensing experiments.
• Characterization using FT-IR, SEM/EDS, and XPS.

Main Results:

• Cd-DBDP was successfully synthesized, exhibiting a negative electrostatic pore environment.
• Cd-DBDP demonstrated selective sensing of guanosine diphosphate (GDP).
• Experimental results aligned with theoretical ESP predictions.
• The sensing mechanism was elucidated through various spectroscopic and computational methods.

Conclusions:

• This work presents the first MOF-based sensor for GDP detection utilizing ESP.
• The findings highlight the importance of matching molecular ESP for effective analyte recognition.
• The study provides a framework for designing advanced MOF sensors for various analytes.