Related Experiment Video
Updated: May 24, 2025
07:40
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
4.7K
Is there a predisposition to uveitis in Turner syndrome?
Kirk A J Stephenson1, Shanil R Dhanji1, Kaivon Pakzad-Vaezi1
1Department of Ophthalmology & Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Ophthalmic Genetics
|March 4, 2025
Summary
Autoimmunity is common in Turner syndrome (TS), but uveitis is rare. This study found TS-associated uveitis is typically acute anterior uveitis responding well to topical treatment, with infrequent relapses.
Area of Science:
- Ophthalmology
- Endocrinology
- Rheumatology
Background:
- Autoimmunity is frequently observed in Turner syndrome (TS).
- Uveitis is an uncommon manifestation in patients with TS.
- A definitive association between TS and uveitis requires further investigation.
Purpose of the Study:
- To report two cases of uveitis in patients with a history of TS.
- To review the existing literature on the relationship between TS, uveitis, and autoimmunity.
Main Methods:
- Case report of two patients with TS and uveitis.
- Comprehensive literature review on TS, uveitis, and autoimmune conditions.
Main Results:
- TS-associated uveitis presents as acute, non-hypertensive anterior uveitis in most cases.
- The condition typically responds well to topical therapy, with rare need for systemic treatment.
- Relapses are infrequent, and long-term visual sequelae are uncommon.
Conclusions:
- Uveitis in TS is generally acute, normotensive, and can be unilateral or bilateral.
- Investigate systemic causes including infectious and non-infectious conditions.
- Systemic immunosuppression is usually unnecessary due to good response to topical therapy; consider TS-related risks before systemic treatment.
More Related Videos
09:39Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
Published on: December 4, 2021
3.0K
10:33Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
2.6K
Related Concept Videos
02:07Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
02:57Meiosis vs. Mitosis
52.2K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
52.2K
01:29Autoimmune Disorders
377
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
377
01:21Nondisjunction
3.7K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.7K
01:19X-linked Traits
53.0K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
53.0K
01:20Disorders of the Urinary System
208
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
208