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Characterizing Mutational Load and Clonal Composition of Human Blood
Published on: July 11, 2019
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Causal relationships between body composition and hematological malignancies: a multivariable mendelian randomization
Shan Liu1, Yaobin Lin2, Zhihong Wang3,4
1Department of Hematology-Oncology, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian Children's Hospital, Fuzhou, Fujian, China.
Cancer Causes & Control : CCC
|March 4, 2025
Summary
Body composition influences cancer risk. Specific body fat and mass measurements are linked to increased leukemia and lymphoma risk, while height and waist-to-hip ratio are independent risk factors for lymphoma and multiple myeloma, respectively.
Area of Science:
- Genetics and Epidemiology
- Cancer Research
- Metabolic Health
Background:
- The link between body composition and hematological malignancies is not well understood.
- This study investigates genetic associations between body composition and blood cancers.
Purpose of the Study:
- To assess the causal relationship between body composition and hematological malignancies using Mendelian randomization (MR).
Main Methods:
- Utilized UK Biobank data from ~500,000 participants (aged 40-69).
- Employed multivariable MR analysis and the inverse-variance weighted (IVW) method.
- Conducted sensitivity analyses to assess heterogeneity and pleiotropy.
Main Results:
- Increased risk of leukemia associated with arm fat-free mass, trunk-predicted mass, whole-body fat-free mass, and whole-body water mass.
- Increased risk of lymphoma linked to various fat and fat-free mass measurements in arms, legs, trunk, and whole body.
- Height is an independent risk factor for lymphoma (OR=1.004, p=0.040).
- Waist-to-hip ratio is a risk factor for multiple myeloma (OR=1.003, p=0.004).
Conclusions:
- Height and waist-to-hip ratio are identified as independent risk factors for specific hematological malignancies.
- Findings support a causal link between body composition and the risk of developing blood cancers.
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