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Scleritis in Iran.

Sahba Fekri1,2, Reza Esmaili Fallah1,2, Masoud Soheilian1,2

  • 1Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic Inflammation and Infection
|March 4, 2025
PubMed
Summary
This summary is machine-generated.

This study details anterior scleritis in Iranian patients, finding it more common in women and often idiopathic. Necrotizing scleritis presented with poorer outcomes, highlighting the need for effective management strategies.

Keywords:
Autoimmune diseaseImmunosuppressantsScleral diseaseScleritisUveitis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Anterior scleritis is an inflammatory eye condition with potential for vision loss.
  • Understanding its presentation in specific populations is crucial for timely diagnosis and treatment.
  • Previous studies on Iranian patients are limited.

Purpose of the Study:

  • To describe the demographic and clinical features of anterior scleritis in Iranian patients.
  • To analyze treatment outcomes and complications.

Main Methods:

  • Retrospective case-series analysis of 65 patients (83 eyes) with anterior scleritis.
  • Data collected included demographics, clinical presentation, systemic associations, therapies, and outcomes.
  • Patients were treated at a tertiary center in Iran from 2008 to 2018.

Main Results:

  • A female predilection (77%) was observed, with a mean age of 44.8 years.
  • Diffuse scleritis was most common; necrotizing scleritis was least common.
  • 61.5% of cases were idiopathic; 28% had bilateral involvement at baseline, increasing to 44.6% eventually.
  • Necrotizing scleritis correlated with worse visual outcomes and more ocular complications.
  • 70.7% of patients received immunosuppressive therapy.

Conclusions:

  • This study provides initial insights into anterior scleritis in Iranian patients.
  • Findings highlight the importance of considering systemic autoimmune diseases.
  • Effective management, including immunosuppression, is vital for improving outcomes.