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Correlation between monocyte and length of in-hospital stay in patients with allergic rhinitis: data from the

Die Fang1, Jing Li1, Ping Fang1

  • 1Department of Otolaryngology, Hangzhou First People's Hospital, Hangzhou, Zhejiang, 310000, China.

BMC Anesthesiology
|March 4, 2025
PubMed
Abstract

Insights

Monocyte levels impact allergic rhinitis (AR) hospital stay length, with white blood cell (WBC) playing a mediating role. Understanding these factors can help optimize AR patient management and reduce hospital stays.

Area of Science:

  • Clinical Medicine
  • Immunology
  • Hematology

Background:

  • Allergic rhinitis (AR) is a common condition impacting patient quality of life and healthcare resource utilization.
  • Length of in-hospital stay (LOS) for AR patients can be influenced by various clinical and laboratory factors.
  • Identifying predictors of LOS is crucial for effective patient management and healthcare planning.

Purpose of the Study:

  • To investigate the factors associated with the length of in-hospital stay (LOS) in patients diagnosed with allergic rhinitis (AR).
  • To determine the independent predictors of LOS in AR patients, considering comorbidities.
  • To explore potential mediating factors influencing the relationship between key variables and LOS.

Main Methods:

  • Retrospective analysis of 937 AR patients from the MIMIC-IV database.
  • Correlation analysis and linear regression to identify factors associated with LOS.
  • Permutation importance and mediation analysis to rank variable significance and explore mediating roles.

Main Results:

  • Ten variables were found to be significantly correlated with LOS in AR patients.
  • Monocyte count, albumin, white blood cell (WBC) count, red blood cell (RBC) count, total calcium, and Charlson comorbidity index were identified as independent predictors of LOS.
  • Monocyte count emerged as the most significant predictor, with WBC mediating its effect on LOS.

Conclusions:

  • Monocyte levels are significantly associated with the length of in-hospital stay in AR patients.
  • White blood cell (WBC) count acts as a mediator in the relationship between monocyte levels and LOS.
  • Stratifying AR patient management based on monocyte levels may aid in clinical decision-making and potentially shorten hospital stays.
Keywords:
Allergic rhinitisLength of stayMIMIC IVMonocyte

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