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Related Experiment Videos

Development of esophageal function.

N E Diamant

    The American Review of Respiratory Disease
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Human esophageal motor function develops after birth, with the upper esophageal sphincter (UES) mature early. The lower esophageal sphincter (LES) shows significant postnatal changes, but its dysfunction link to infant reflux remains unclear.

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    Area of Science:

    • Pediatric Gastroenterology
    • Developmental Physiology

    Background:

    • Esophageal motor function development in humans is not well understood.
    • Anatomical growth of the esophagus and sphincters occurs postnatally.

    Purpose of the Study:

    • To review the developmental trajectory of human esophageal motor function.
    • To elucidate the maturation of the upper esophageal sphincter (UES) and lower esophageal sphincter (LES).

    Main Methods:

    • Literature review of studies on infant esophageal motility.
    • Analysis of data on UES and LES pressure and function development.

    Main Results:

    • The UES is developed at birth with minimal postnatal functional maturation.
    • Esophageal body sucking and swallowing mature rapidly in term infants, slower in premature infants.

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  • The LES pressure is low at birth, rises above adult levels by 6 months, then decreases to adult levels by 1-3 years, suggesting bulk increase.

    • Conclusions:

    • Postnatal development of esophageal motor function varies between sphincters and the esophageal body.
    • Further research is needed to assess neural maturation and muscle responsiveness of the LES.
    • The connection between LES dysfunction, infant gastroesophageal reflux, and pulmonary issues requires further investigation.