Age-Dependent Spatial Patterns of Brain Noise in fMRI Series

Functional Magnetic Resonance Imaging (fMRI) serves as a unique non-invasive tool for investigating brain function by analyzing blood oxygenation level-dependent (BOLD) series. These signals result from the complex interplay between deterministic and stochastic components underpinning biological brain activity. In this context, the quantification of the stochastic component, here defined as brain noise, is challenging without making assumptions on the deterministic dynamics. Leveraging on Approximate Entropy, in this study we present a methodological framework aimed to estimate intrinsic stochastic brain dynamics through fMRI data analysis without making assumption on the deterministic model. We estimated brain noise from fMRI series of 200 participants from the publicly available Cam-CAN dataset, aiming to quantify the amount of stochastic dynamics in different brain regions. Moreover, we hypothesize that a functional relationship exists between intrinsic brain noise and subject's age. Results indicate that a significant part - approximately 18% to 60% - of the fMRI signal power can be attributed to the intrinsic stochastic dynamics within the brain, and a linear augmentation is reported in association with the maturation process. These findings underscore the physiological importance of characterizing neural noise and its unique distributions across various brain regions.