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Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System

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A Robust BLE-compatible Wake-up Receiver for Ingestible Device with In-vivo Evaluation.

Saebyeok Shin, Yeseul Jeon, Ian Ballinger

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|March 5, 2025

Summary

This study introduces a new Bluetooth Low Energy (BLE)-compatible wake-up receiver (WuRx) for ingestible devices. It enables reliable communication in the GI tract with ultra-low power consumption.

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Area of Science:

Biomedical Engineering
Wireless Communication Systems
Gastrointestinal Healthcare

Background:

Ingestible devices are crucial for gastrointestinal (GI) tract healthcare monitoring.
Communication challenges exist for devices operating within the human GI tract.
The 2.4 GHz frequency band is a promising option for wireless communication.

Purpose of the Study:

To develop a low-power, Bluetooth Low Energy (BLE)-compatible wake-up receiver (WuRx) for ingestible devices.
To address communication signal loss within the GI tract.
To reduce power consumption for extended device operation.

Main Methods:

Proposed a BLE-compatible WuRx operating at 2.48 GHz.
Utilized an LNA-first receiver architecture for enhanced sensitivity (-81 dBm).
Implemented a low-power single clock chain with Film Bulk Acoustic Resonator (FBAR) and duty cycling.

Main Results:

The proposed WuRx achieved -81 dBm sensitivity, overcoming GI tract signal loss.
The design demonstrated an average power consumption of 0.11 µW with a 1% duty cycle.
In-vivo testing validated the performance of the proposed ingestible device communication system.

Conclusions:

This work presents the first BLE-compatible WuRx specifically designed for low-power ingestible devices.
The developed technology significantly enhances communication reliability and power efficiency for GI tract monitoring.
The system holds potential for a wide range of future medical applications in ingestible healthcare.