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Published on: July 9, 2021
Optimizing dipole-dipole relaxation resilience to off-resonance fields during adiabatic T1ρ
Abstract:
Quantitative MRI measurements with adiabatic T1ρ can provide sensitive markers to pathological alterations in the presence of system imperfections, especially at high field strengths. However, the mechanisms behind T1ρ,adiab relaxation during adiabatic RF pulses are complex and present strong dependence on the pulse design. The aim of this study is to investigate the resilience of T1ρ,adiab times measured during adiabatic RF irradiation to B0 inhomogeneities, considering both T1ρ dispersion and inversion efficiency. Redfield relaxation theory is used to study the effect of off-resonance on the efficiency of the underlying relaxation processes and Bloch simulations are used to investigate the pulse efficiency. Joint optimization of hyperbolic secant adiabatic pulses yields optimal off-resonance resilience for β=5.9 and moderate FM amplitude≈1500 Hz. For this combination the off-resonance-induced dispersion is seven-fold reduced when compared to pulses obtained with conventional Bloch simulations only. The proposed optimization provides promising candidates for robust T1ρ,adiab preparation pulses for in vivo applications at 3T.
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