Structure Preserving Cycle-Gan for Unsupervised Medical Image Domain Adaptation

The presence of domain shift in medical imaging is a common issue, which can greatly impact the performance of segmentation models when dealing with unseen image domains. This work introduces the Structure Preserving Cycle-GAN (SP Cycle-GAN) for unsupervised domain adaptation (DA) of segmentation datasets, which promotes medical structure preservation during image translation through the enforcement of a segmentation loss term in the overall Cycle-GAN training process. We demonstrate the structure preserving capability of the SP Cycle-GAN both visually and through comparison of Dice score segmentation performance for the un-supervised domain adaptation models. The SP Cycle-GAN is able to outperform baseline approaches and standard Cycle-GAN domain adaptation for binary blood vessel segmentation in the STARE and DRIVE datasets, and multi-class Left Ventricle (LV) and Myocardium segmentation in the multi-modal MM-WHS dataset. SP Cycle-GAN achieved a state of the art Myocardium segmentation Dice score (DSC) of 0.7435 for the MR to CT MM-WHS domain adaptation problem.