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Updated: May 24, 2025
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
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Clinical Findings in Symptomatic Patients With Radiologically Isolated Sphenoid Sinus Disease: A Systematic Review
Zahir Mughal1, Keshav Kumar Gupta2, Karan Jolly2
1Department of ENT, Walsall Manor Hospital, Walsall, UK.
Summary
Headache is the most common symptom of isolated sphenoid sinus disease (ISSD), followed by nasal and visual issues. Nasal endoscopy is often unreliable for diagnosing ISSD.
Area of Science:
- Otolaryngology
- Radiology
- Medical Diagnostics
Background:
- Isolated sphenoid sinus disease (ISSD) presents diagnostic challenges.
- Understanding its clinical manifestations is crucial for timely diagnosis and management.
Purpose of the Study:
- To systematically review and synthesize the clinical presentations of ISSD.
- To determine the pooled prevalence of symptoms and signs associated with ISSD.
Main Methods:
- A comprehensive literature search was performed across major electronic databases.
- Meta-analysis of proportions was used to calculate the prevalence of clinical findings.
- Sensitivity and subgroup analyses were conducted to explore heterogeneity.
Main Results:
- Headache was the most frequent symptom (67.9%), followed by nasal symptoms (29.7%) and visual disturbance (14.0%).
- Neoplastic ISSD showed a higher prevalence of visual symptoms compared to inflammatory types (38.3% vs. 15.5%).
- Nasendoscopy yielded negative results in 52.0% of cases, indicating a high false-negative rate.
Conclusions:
- Headache is the cardinal symptom of ISSD.
- The high false-negative rate of nasendoscopy underscores the importance of cross-sectional imaging for diagnosis.
- Recognizing these clinical features can prompt earlier investigation for ISSD.
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