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Transcriptomics and microbiome insights reveal the protective mechanism of mulberry-derived postbiotics against

Zaheer Abbas1, Yucui Tong1, Jing Zhang1

  • 1State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Frontiers in Immunology
|March 5, 2025
PubMed
Abstract

Insights

Mulberry-derived postbiotics (MDP) protect against inflammation and gut damage in mice. MDP treatment also influences gut microbiota, suggesting potential as a food additive for immune and gut health.

Area of Science:

  • Immunology
  • Gastroenterology
  • Nutraceuticals

Background:

  • Natural bioactive compounds are explored for immune modulation and gut health.
  • Mulberry-derived postbiotics (MDP) show potential for managing inflammation in metabolic disorders.

Purpose of the Study:

  • To investigate the protective effects of MDP against inflammation in LPS-induced mice.
  • To elucidate the mechanisms underlying MDP's effects using transcriptomic and microbiome analyses.

Main Methods:

  • LPS-induced inflammation model in mice.
  • Transcriptomic profiling (gene expression analysis).
  • Microbiome analysis.
  • Gene enrichment (GO, KEGG) and protein-protein interaction analyses.

Main Results:

  • MDP pretreatment mitigated LPS-induced intestinal damage and improved villous morphology.
  • Transcriptomic analysis revealed significant alterations in gene expression related to immune and inflammatory pathways.
  • Key inflammatory hub genes (IL6, CXCL10, MYD88) were identified in the LPS group, while MDP treatment modulated genes like CD74, CIITA, and H2-AB1.
  • MDP influenced gut microbiota composition, potentially contributing to systemic immune regulation.

Conclusions:

  • MDP demonstrates protective effects against inflammation and intestinal damage.
  • MDP may modulate the gut microbiota, supporting immune homeostasis.
  • MDP holds promise as a functional food additive for enhancing immune function and gut health.
Keywords:
gut microbiotaimmune responselipopolysaccharidesmulberry-derived postbioticstranscriptomics

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