Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

5.9K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
5.9K
Nucleic acids02:43

Nucleic acids

158.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
158.0K
DNA as a Genetic Template02:05

DNA as a Genetic Template

21.6K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.6K
DNA Packaging00:58

DNA Packaging

101.9K
Overview
101.9K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

46.6K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
46.6K
Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

8.6K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure-Controlled Molecular Recognition and Charge Transport in Metallized DNA Nanosheets.

Journal of the American Chemical Society·2026
Same author

DNA Framework Nucleator-Enabled Intelligent Hydrogel Interfaces on Living Cells.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Machine learning-directed massively parallel programmable nucleic acid amplification.

Science advances·2026
Same author

Target-Gated Ratiometric pH Sensing via Tetrahedral DNA Framework-Based Dual-CRISPR System.

Analytical chemistry·2026
Same author

DNA Framework-Encoded Digital Recorder for Bacterial Discrimination.

ACS nano·2026
Same author

DNA framework-based molecular transformer for logic-driven precision diagnostics.

Science advances·2026
Same journal

Bioelectrode Healing via Engineered Electrode Reconstruction on Biofilms under Strong Acid and Ultrahigh Current Density.

Chem & bio engineering·2026
Same journal

Ultrarapid Purification of Manganese-52 from Chromium-52 Targets via Potentiostatic Anodic Dissolution and Chelation Ion Chromatography.

Chem & bio engineering·2026
Same journal

Nanoengineered All-Cellulose Bilayer Barrier Papers for High-Performance and Recyclable Food Packaging.

Chem & bio engineering·2026
Same journal

New Frontiers in AI-Nano Converged Platforms for Intelligent Diagnostics, Therapeutics, and Safety Evaluation.

Chem & bio engineering·2026
Same journal

Strategies for Mitigation of Intermediate CO<sub>2</sub> Poisoning to Promote Electrocatalytic Efficiency during Urea Oxidation Reaction.

Chem & bio engineering·2026
Same journal

Modular Biosurface Engineering of Magnetotactic Bacteria for Multimodal Synergistic Cancer Therapy.

Chem & bio engineering·2026
See all related articles

Related Experiment Video

Updated: May 24, 2025

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.5K

Nucleic Acid Framework-Enabled Spatial Organization for Biological Applications.

Rui Zhang1,2, Xiaolei Zuo1,3, Fangfei Yin1,3

  • 1Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Chem & Bio Engineering
|March 5, 2025
PubMed
Summary
This summary is machine-generated.

Nucleic acid frameworks (NAFs) offer precise control over molecular organization for nanotechnology. These DNA-based structures enable biomimicking, biosensing, and nanomedicine applications.

More Related Videos

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

408.7K
High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

17.9K

Related Experiment Videos

Last Updated: May 24, 2025

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.5K
Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

408.7K
High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

17.9K

Area of Science:

  • Nanotechnology
  • Biochemistry
  • Synthetic Biology

Background:

  • Nucleic acid frameworks (NAFs) are artificial structures created from natural nucleic acids with defined size and shape.
  • DNA origami allows for controllable 2D lamellar structures, facilitating the construction of diverse 3D nanostructures.
  • Tetrahedral DNA nanostructures (TDNs) utilize four DNA strands to form a tetrahedral geometry.

Purpose of the Study:

  • To review molecular spatial organization using DNA origami and TDNs as models for 2D and 3D recombination.
  • To discuss NAF-based biomimicking of proteins and biomembranes.
  • To introduce NAF applications in biosensing, bioimaging, and nanomedicine therapy.

Main Methods:

  • Utilizing DNA origami for controllable 2D and 3D nanostructure construction.
  • Employing tetrahedral DNA nanostructures (TDNs) for specific molecular assembly.
  • Incorporating identification probes, functional groups, and intercalators for enhanced functionality.

Main Results:

  • NAFs demonstrate precise molecular spatial organization and are adaptable for biomimicking and nanoparticle formation.
  • NAFs serve as versatile platforms for interdisciplinary applications in nanotechnology, biochemistry, synthetic biology, and nanomedicine.
  • Functionalized NAFs enable advancements in biosensing, bioimaging, and targeted nanomedicine therapies.

Conclusions:

  • Nucleic acid frameworks provide a powerful platform for advanced nanotechnology and interdisciplinary research.
  • The precise organization and functionalization capabilities of NAFs drive innovation in biomimicking and nanomedicine.
  • NAFs are crucial for developing sophisticated tools in synthetic biology, biochemistry, and materials science.