Related Experiment Video
Updated: Jun 26, 2026

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
Published on: July 25, 2014
Digging through the (Statistical) Dirt: A Reproducible Method for Single-Molecule Flicker Noise Analysis
James M F Morris1,2, Jarred Potter3, Demetris Bates1
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom.
Abstract:
Flicker noise analysis has found widespread use in the molecular electronics community over the past 9 years. The noise power of the junctions and the value of its scaling exponent n provide information on the spatial overlap of scattering states in single-molecule junctions and give unique insights into quantum transport phenomena at the single-molecule level. The predominant drawback of this analytical tool is the inconsistency of the methodologies employed, resulting in irreproducibility across data sets acquired in different conditions or in different laboratories. Herein, we provide a pathway to a more reproducible methodology, detailing issues with the currently accepted correlation techniques employed and introducing the use of more statistically robust data processing criteria and lower thresholds for data acquisition parameters.
Related Concept Videos
¹³C NMR: ¹H–¹³C Decoupling
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
Mass Analyzers: Overview
Sampling Methods: Overview
In analytical chemistry, the choice of sampling...
Sample Preparation for Analysis: Advanced Techniques
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Double Resonance Techniques: Overview
Spin decoupling is usually achieved by...

