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How does a Bacillus split its septum right down the middle?

A L Koch, G Kirchner, R J Doyle

    Annales De L'Institut Pasteur. Microbiologie
    |January 1, 1985
    PubMed
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    Gram-positive cells ensure even cell division through two proposed mechanisms: protonmotive force inhibiting autolysins and tensional stress on the cross-wall. Both processes likely contribute to precise cell fission for bacterial growth.

    Area of Science:

    • Microbiology
    • Cell Biology
    • Biophysics

    Background:

    • Bacterial cell division requires precise duplication and separation of cellular components.
    • Gram-positive bacteria utilize a cross-wall during cell fission.
    • The even thickness of daughter cell poles is crucial for viability.

    Purpose of the Study:

    • To explore speculative mechanisms for achieving uniform thickness in Gram-positive cell division.
    • To investigate the role of protonmotive force and tensional stress in regulating autolysin activity.

    Main Methods:

    • Theoretical consideration of biophysical forces during cell division.
    • Modeling the influence of protonmotive force on enzyme activity.
    • Analyzing the impact of mechanical stress on autolysin function.

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    Main Results:

    • Protonmotive force may inhibit autolysins within approximately 25 nm of the cytoplasmic membrane.
    • Tensional stress on the cross-wall can accelerate autolysin function.
    • Both mechanisms are proposed to contribute to the even bisection of the cross-wall.

    Conclusions:

    • Gram-positive cell division likely employs a dual mechanism involving proton gradients and mechanical stress.
    • These integrated processes ensure the symmetrical formation of daughter cell poles.
    • Further research is needed to experimentally validate these speculative models.