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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

1
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
1

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Hyperbaric Oxygen Therapy (HBOT) in Moderate Traumatic Brain Injury (TBI): A Randomized Controlled Trial.

Jitender Chaturvedi1, Vishal Mago2, Mohit Gupta1

  • 1Department of Neurosurgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

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Hyperbaric oxygen therapy (HBOT) significantly improved Glasgow Coma Scale scores at discharge and Glasgow Outcome Scale-Extended scores at 3 months for moderate traumatic brain injury (TBI) patients. This novel treatment offers a promising adjunctive therapy for TBI recovery.

Keywords:
HBOTTBIhyperbaric oxygen therapymoderatetraumatic brain injury

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Area of Science:

  • Neurology
  • Hyperbaric Medicine
  • Trauma Care

Background:

  • Traumatic brain injury (TBI) involves complex secondary injury cascades including inflammation and oxidative stress.
  • Hyperbaric oxygen therapy (HBOT) increases oxygen availability to tissues, potentially mitigating secondary brain injury.
  • HBOT is being investigated as an adjunctive treatment to improve outcomes in TBI patients.

Purpose of the Study:

  • To evaluate the efficacy of adjuvant hyperbaric oxygen therapy (HBOT) in patients with moderate TBI.
  • To compare Glasgow Coma Scale (GCS) at discharge and Glasgow Outcome Scale-Extended (GOS-E) at 3 months between HBOT and standard care groups.

Main Methods:

  • A randomized controlled study included moderate TBI patients receiving standard care.
  • The treatment group received adjuvant daily HBOT sessions (1.4 ATM, 60 minutes) for 10 consecutive days.
  • GCS at discharge and GOS-E at 3 months were the primary outcome measures.

Main Results:

  • Patients receiving HBOT showed a statistically significant improvement in mean GCS at discharge (14.37 vs. 13.40, p < 0.001).
  • The HBOT group also demonstrated significantly higher mean GOS-E scores at 3 months post-injury (7.62 vs. 6.40, p < 0.001).
  • Results indicate a significant benefit of adjuvant HBOT for moderate TBI recovery.

Conclusions:

  • Early adjuvant HBOT (1.4 ATM, 1-hour daily for 10 days) significantly improves GCS at discharge in moderate TBI patients.
  • Adjuvant HBOT is associated with significantly improved GOS-E at 3 months post-injury compared to standard care alone.
  • HBOT represents a promising adjunctive therapy for enhancing recovery in moderate TBI.