Self-Reported Adverse Events Following COVID-19 Vaccination Among Medical Sciences Students After a Symptomatology
Taraneh Tavanaei Tamanaei1, Mohammad Bagher Oghazian2,3, Mehran Mojtabaee4
1Lung Diseases Research Center Mashhad University of Medical Sciences Mashhad Iran.
Health Science Reports
|March 5, 2025
Summary
Adverse events (AEs) were more common after the first dose of Oxford-AstraZeneca compared to Sinopharm COVID-19 vaccines. Sex and vaccine type influenced AE prevalence, with higher odds in women.
Area of Science:
- Medical Sciences
- Vaccinology
- Public Health
Background:
- Accurate investigation of adverse events (AEs) following COVID-19 vaccination is crucial for public trust.
- This study assessed COVID-19 vaccine-related AEs in medical students.
Purpose of the Study:
- To evaluate and compare the prevalence of AEs after Oxford-AstraZeneca (AZD1222) and Sinopharm (BBIBP-CorV) COVID-19 vaccines.
- To identify factors influencing the occurrence of AEs.
Main Methods:
- A cross-sectional study involving 263 medical sciences students.
- Self-administered surveys via Google Forms were used to collect data.
- A training program was implemented to minimize confirmation bias in AE reporting.
Main Results:
- The first dose of Oxford-AstraZeneca was associated with significantly higher AE prevalence than Sinopharm [OR 12.93].
- No significant difference in AE prevalence was observed between the vaccines after the second dose [OR 1.45].
- Common AEs included injection site pain, fever, body/muscle pain, headache, fatigue; women reported higher odds of AEs.
Conclusions:
- The Oxford-AstraZeneca vaccine showed a higher AE prevalence compared to Sinopharm, particularly after the first dose.
- Vaccine type and sex were significant factors influencing AE occurrence.
- Standardized definitions for COVID-19 vaccine AEs are needed for consistent reporting.
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