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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Dynamic Pathophysiological Insight into the Brain by NIR-II Imaging.

Si Chen1,2, Hao Chen2,3, Xinxin Li3

  • 1Department of Neurology, Xiangya Hospital, Central South University, Xiangya Road 88, Changsha, 410008, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 5, 2025
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Summary
This summary is machine-generated.

New organic nanoprobes enable detailed in vivo imaging of brain blood flow and blood-brain barrier integrity. This advance aids understanding of neurological diseases and potential interventions.

Keywords:
BBB disruptionNIR‐II fluorescencecerebral collateral circulationcrystalline organic nanoprobelive‐brain imaging

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Cerebral collateral circulation and blood-brain barrier (BBB) are vital for brain function.
  • Current diagnostic tools have limitations in assessing dynamic neurovascular unit function.
  • Understanding collateral perfusion and BBB changes in disease is limited.

Purpose of the Study:

  • To develop and evaluate novel nanoprobes for in vivo brain vascular imaging.
  • To assess the potential of these nanoprobes for visualizing collateral circulation and BBB integrity.
  • To explore applications in neurological disease models.

Main Methods:

  • Synthesis of highly crystalline semiconducting organic nanoprobes (4T-BSA) from small-molecule dye and bovine serum albumin.
  • In vivo live-brain vascular imaging in the second near-infrared window (NIR-II, 1000-1700 nm).
  • Evaluation of imaging penetration depth, signal-to-background ratio (SBR), and spatial resolution in mouse models.

Main Results:

  • 4T-BSA nanoprobes demonstrated superior imaging penetration depth in intact mouse brains.
  • Achieved high SBR (6.0) and sub-50-µm spatial resolution of cerebral vasculature.
  • Successfully visualized vascular collateral perfusion and albumin leakage in neurological disease models.
  • Identified pathological activities related to collateral flow networks and BBB disruption.

Conclusions:

  • 4T-BSA nanoprobes are highly effective for live-brain vascular imaging in the NIR-II window.
  • These nanoprobes provide valuable insights into cerebral collateral circulation and BBB integrity.
  • NIR-II imaging holds promise for advancing diagnosis and treatment of neurological diseases.